Aurora kinase inhibitor in breast cancer

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Skip to search form Skip to main content. Desai and J. Ginther and Lee F.

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Menu Contact Dictionary Search. What Is Cancer? Cancer Statistics.

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Aberrant expression of Aurora kinases has been demonstrated in certain malignancies. We aimed to examine the expression of Aurora kinases in human breast cancer tissues and to investigate the cellular impact of Aurora kinases inhibitor on breast cancer cells. Cells were treated with the corresponding inhibitor, and then migration and adhesion were evaluated by electric cell impedance sensing assay.

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Major gynecological types of cancer, including cervical, endometrial, ovarian and vulvar cancer, are a cause of concern in females. Diagnosis at advanced stages leads to increased morbidity and mortality, in contrast to an early diagnosis, which increases the chance of a cure and has correspondingly improved survival rates. Diagnostic factors, including age, histology, race, histological grade and stage at diagnosis, along with clinical phenotypes and the degree of causal association of human papillomavirus HPV infection 3and the disease mechanisms of the five aforementioned cancer types appear to be distinct and precise 1. Extensive efforts have been made over recent decades to identify diagnostic genes and develop mechanisms for recognizing cancer in individuals 1.

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Tyrosine and aurora kinases are important effectors in signal transduction pathways that are often involved in aberrant cancer cell growth. However, ABC transporters are prominently expressed in the liver and other eliminating organs, and their inhibition has been linked to intracellular accumulation of drugs, altered disposition, and toxicity. Such analysis identified several potentially clinically relevant inhibitors of MRP4: alisertib, danusertib, erlotinib, lapatinib, neratinib, nilotinib, pazopanib, sorafenib, and tozasertib.

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Please take this quick survey to tell us about what happens after you publish a paper. Breast Cancer Research and Treatment. Combination of alisertib and FRAX was evaluated in a panel of 13 human breast tumor cell lines and BT xenograft model, with assessment of the cell cycle by FACS, and signaling changes by immunohistochemistry and Western blot.

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Ovarian cancer OC is the most lethal gynecologic malignancy in the Western world, with an estimated 22, new cases and 14, deaths in the U. Although most patients initially respond to surgical debulking and chemotherapy, the majority will experience recurrent disease that has become drug resistant [ 12 ]. These statistics suggest that there is room for improvement in our approach to steering oncology drugs from the bench to the bedside.

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Approximately the first 10 participants enrolled in this arm will be administered midazolam. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.

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